Cephalomannine CAS 71610-00-9

Introduction：Basic information about Cephalomannine CAS 71610-00-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Cephalomannine Basic information

• Product Name: Cephalomannine
• Synonyms: TAXOL B;BENZENEPROPANOICACID,ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-;BENZENEPROPANOIC ACID, ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OXET-9-YL ESTER,[2AR-[2A,4,4A,6,9[R*,S*(E)],11,12,12A,12B]]-;CEPHALOMANNINE;paclitaxel iMpurity I;CephaloMannine, froM Taxus chinensis;(αR,βS)-α-Hydroxy-β-[[(2E)-2-Methyl-1-oxo-2-buten-1-yl]aMino]benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester;NSC 318735
• CAS: 71610-00-9
• MF: C45H53NO14
• MW: 831.9
• Product Categories: Inhibitors;Alkaloids;Antineoplastic and Immunosuppressive AntibioticsEnzyme Inhibitors by Enzyme;DNA polymerase - alphaAntibiotics;Antibiotics;Antibiotics A to;Antibiotics A-FAntibiotics;Antibiotics by Application;Chemical Structure Class;D to;Interferes with DNA SynthesisAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);Herb extract;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Impurities
• Mol File: 71610-00-9.mol

Cephalomannine Chemical Properties

• Melting point: 139-141?C
• Boiling point: 929.5±65.0 °C(Predicted)
• density: 1.36±0.1 g/cm3(Predicted)
• storage temp.: -20°C Freezer
• solubility: DMSO: 14 mg/mL, soluble
• pka: 11.95±0.20(Predicted)
• form: solid
• color: White to Pale Beige
• InChIKey: DBXFAPJCZABTDR-WBYYIXQISA-N
• CAS DataBase Reference: 71610-00-9

Safety Information

• Hazard Codes: Xi
• Risk Statements: 37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• HS Code: 29329990

Cephalomannine Usage And Synthesis

Chemical Properties

Off-White Solid

Occurrence

A taxane derivative, cephalomannine occurs in the extract of Cephalotaxus rnannii. It has been obtained as colourless needles from MeOH aq. and is laevorotatory with a specific rotation of [α]D -41° (MeOH).

Uses

Cephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice. Cephalomannine is a chemotherapy drug that is given as a treatment for some types of cancer. Cephalomannine is most com

Uses

Antitumor, antiproliferative.

Uses

similar anti-cancer function as Taxol

in vivo

Cephalomannine (0.4 mg/kg, intraperitoneal injection, 10 days) could significantly inhibit the growth of lung cancer cells in nude mice xenograft model, with no obvious side effects^[3].
Cephalomannine can interrupt the interaction between APEX1 and HIF-1α by competitive binding with APEX1^[3].

• Animal Model: BALB/C nude mice xenograft model^[3]
• Dosage: 0.4 mg/kg
• Administration: Intraperitoneal injection (i.p.)
• Result: Reduced the volume and weight of H460 xenograft tumors.

• Animal Model: BALB/c nude mice bone metastasis xenograft model^[4]
• Dosage: 10 mg/kg, 20 mg/kg
• Administration: Intraperitoneal injection (i.p.)
• Result: Decreased bone destruction, reduced bioluminescence intensity and number of bone metastases, significantly extended time to endpoint events, decreased UBE2S expression and number of osteoclasts, and did not produce significant toxicity to the heart, liver, or kidney of nude mice.

IC 50

HIF-1α

Cephalomannine Preparation Products And Raw materials

• Raw materials: TIGLOYL CHLORIDE