CINCHONINE HYDROCHLORIDE CAS 5949-11-1

Introduction：Basic information about CINCHONINE HYDROCHLORIDE CAS 5949-11-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

CINCHONINE HYDROCHLORIDE Basic information

• Product Name: CINCHONINE HYDROCHLORIDE
• Synonyms: Cinchonine monohydro;(S)-Quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol hydrochloride;cinchonine,monohydrochloride;monohydrochloride,(9s)-cinchonan-9-o;CINCHODININE DIHYDROCHLORIDE;CINCHONINE HYDROCHLORIDE;(+)-CINCHONINE HYDROCHLORIDE N-HYDRATE;CINCHONINE HYDROCHLORIDE N-HYDRATE
• CAS: 5949-11-1
• MF: C19H23ClN2O
• MW: 330.85
• EINECS: 621-239-2
• Product Categories: Alkaloids;Biochemistry;for Resolution of Acids;Optical Resolution;Quinoline Alkaloids;Quinolinecarboxylic Acids, etc.;Quinolines;Synthetic Organic Chemistry
• Mol File: 5949-11-1.mol

CINCHONINE HYDROCHLORIDE Chemical Properties

• Melting point: 208-218 °C(lit.)
• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5949-11-1

Safety Information

• Hazard Codes: Xn,Xi
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 36/37-36-26
• RIDADR: 1544
• WGK Germany: 3
• RTECS: GD2962020
• F: 8
• HazardClass: 6.1(b)
• PackingGroup: III

CINCHONINE HYDROCHLORIDE Usage And Synthesis

Description

Cinchonine hydrochloride not only possesses the required solubility and bioavailability criteria for pharmaceutical formulations while retaining desired therapeutic properties, but is also very stable in solution, which facilitates the preparation of aqueous formulations, especially injections.

Uses

Cinchonine hydrochloride can be used as an inhibitory substance for the phenomenon of "multidrug resistance" (MDR). In particular, cinchonine hydrochloride compositions are useful in the treatment of cancer-related diseases with MDR phenomena.

Biological Activity

Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural compound in cinchona bark with antimalarial activity. It can activate endoplasmic reticulum stress to induce apoptosis in human hepatoma cells.