Coptisine chloride CAS 6020-18-4

Introduction：Basic information about Coptisine chloride CAS 6020-18-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Coptisine chloride Basic information

• Product Name: Coptisine chloride
• Synonyms: 2,3,9,10-BISMETHYLENEDIOXYPROTOBERBERINE;COPTISINE CHLORIDE;COPTISINE CHLORIDE(P);7,8,13,13a-Tetradehydro-2,3:9,10-bis(methylenedioxy)berbinium chloride;Coptisine Hcl;Coptisine Hydrochloride;COPTISINECHLORIDE(P)(PLEASECALL);6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinoliziniuM Chloride
• CAS: 6020-18-4
• MF: C19H14ClNO4
• MW: 355.77
• EINECS: 611-948-5
• Product Categories: pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;chemical reagent;Amines;Heterocycles;Inhibitor;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 6020-18-4.mol

Coptisine chloride Chemical Properties

• Melting point: >258°C (dec.)
• storage temp.: Inert atmosphere,2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• form: Solid
• color: Orange to Dark Orange
• Stability: Hygroscopic
• Major Application: metabolomics vitamins, nutraceuticals, and natural products
• InChI: InChI=1S/C19H14NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,5-8H,3-4,9-10H2;1H/q+1;/p-1
• InChIKey: LUXPUVKJHVUJAV-UHFFFAOYSA-M
• SMILES: C12=CC3=C(C4OCOC=4C=C3)C=[N+]1CCC1C=C3OCOC3=CC2=1.[Cl-]

Safety Information

• WGK Germany: WGK 3
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
• Hazard Classifications: Acute Tox. 2 Inhalation Acute Tox. 2 Oral

Coptisine chloride Usage And Synthesis

Chemical Properties

Orange Brown Solid

Uses

Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis). A bacterial collagenase inhibitor. Coptisine has been found to reversibly inhibit Monoamine oxidase A in mice, pointing to a potential role as a natural antidepressant.

in vivo

Coptisine shows increased toxicity in mice in a concentration dependent manner, with LD₅₀ value of 880.18 mg/kg. Coptisine (154 mg/kg/day, 90 days) shows no toxicity on SD rats. Coptisine (23.35, 46.7, 70.05 mg/kg, p.o.) dose-dependently decreases the levels of TC, TG, and LDL-c and increases HDL-c content in serum of hamsters to different degree, slows down weight gain induced by the HFHC diet, and raises the level of cholesterol and TBA in feces dose-dependently in hamsters. Coptisine (70.05 mg/kg, p.o.) suppresses HMGCR protein expression level and induces the protein expression of SREBP-2, LDLR, and CYP7A1 involved in cholesterol metabolism^[2].

IC 50

IDO: 6.3 μM (IC₅₀); IDO: 5.8 μM (Ki)