Introduction：Basic information about Dynorphin A (1-13) CAS 72957-38-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Dynorphin A (1-13) Basic information
| Product Name: | Dynorphin A (1-13) |
| Synonyms: | TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS;TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS 5ACOH 6H2O;TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS PORCINE;YGGFLRRIRPKLK;L-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS;DYNORPHIN A PORCINE FRAGMENT 1-13;DYNORPHIN A(HUMAN, 1-13);DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE) |
| CAS: | 72957-38-1 |
| MF: | C75H126N24O15 |
| MW: | 1603.95 |
| EINECS: | 635-974-1 |
| Product Categories: | Opioid receptor and opioid-like receptor;peptide;DynorphinsPeptides for Cell Biology;Dynorphins;Neuropeptides;Opioid Peptides |
| Mol File: | 72957-38-1.mol |
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Dynorphin A (1-13) Chemical Properties
| density | 1.39±0.1 g/cm3(Predicted) |
| RTECS | JV7436666 |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| form | Solid |
| pka | 3.31±0.10(Predicted) |
| color | White to off-white |
| Water Solubility | Water: ≥ 60 mg/mL (37.41 mM) |
| Sequence | H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH |
| Cosmetics Ingredients Functions | ANTI-SEBUM
SKIN PROTECTING |
| InChIKey | OVVIBUHLQIYUEU-JASZZEBFNA-N |
Safety Information
| WGK Germany | 3 |
| HS Code | 2933998090 |
Dynorphin A (1-13) Usage And Synthesis
| Description | Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1-13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1-13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma[1]. |
| Uses | Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations. |
| Application | Dynorphin A (1-13) has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS). |
| Biochem/physiol Actions | Dynorphin A (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca2+]i level and contributes to the loss of neurons affecting neuronal viability. |
| in vivo | Dynorphin A (1-13) exposure (33 μM) causes a significant loss in neuronal viability at 4 h with a visible destruction in neuronal morphology seen at 16 h. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acute NMDA treatment. Continuous exposure to dynorphin A (1-13) (100 μM) causes a significant loss of neurons over time[1]. |
| IC 50 | κ Opioid Receptor/KOR |
| References | [1] B BRUGOS; G H. Metabolism of dynorphin A(1-13).[J]. Pharmazie, 2004. |
Dynorphin A (1-13) Preparation Products And Raw materials
| Raw materials | L-Lysine, N-[(phenylmethoxy)carbonyl]-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N5-[imino[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino]methyl]-L-ornithyl-N5-[imino[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino]methyl]-L-ornithyl-L-isoleucyl-N5-[imino[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino]methyl]-L-ornithyl-L-prolyl-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysyl-L-leucyl-N6-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester |
