Endothelin-1 (human, porcine) CAS 117399-94-7
Introduction：Basic information about Endothelin-1 (human, porcine) CAS 117399-94-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Endothelin-1 (human, porcine) Basic informationDescription
| Product Name: | Endothelin-1 (human, porcine) |
| Synonyms: | ET-1;ET-1, HUMAN;ET-1, HUMAN AND PORCINE;ET-1 (HUMAN, BOVINE, DOG, MOUSE, PORCINE, RAT);ET-1 (HUMAN, MOUSE, RAT, PIG, BOVINE, DOG);ET-1, HUMAN, PORCINE;ET-1 (HUMAN, PORCINE, DOG, RAT);ENDOTHELIN-I, HUMAN, PORCINE |
| CAS: | 117399-94-7 |
| MF: | C109H159N25O32S5 |
| MW: | 2491.9 |
| EINECS: | |
| Product Categories: | amino;Peptide;Endothelin receptor |
| Mol File: | 117399-94-7.mol |
Endothelin-1 (human, porcine) Chemical Properties
| Boiling point | 2467.3±65.0 °C(Predicted) |
| density | 1.273±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | 1% acetic acid: >1 mg/mL |
| form | powder |
| color | white |
| biological source | Porcine human |
| Water Solubility | Soluble in water. |
| Merck | 13,3610 |
| Sequence | Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: Cys1-Cys15, Cys3-Cys11) |
| InChIKey | ZUBDGKVDJUIMQQ-UHFFFAOYSA-N |
Safety Information
| WGK Germany | 3 |
| RTECS | KE9446500 |
| F | 3-10 |
| HS Code | 2937190000 |
| Storage Class | 11 - Combustible Solids |
| Description | Endothelin-1 (human, porcine) is an active peptide with strong vasoconstriction effect isolated from the supernatant of cultured porcine aortic endothelial cells. Endothelin 1 has been shown to be present in many mammals, including humans. Although vascular endothelial cells are the main source of endothelin 1, cardiomyocytes, vascular smooth muscle cells, renal tubular epithelial cells and glial cells can all produce endothelin 1, suggesting that endothelin 1 can independently participate in the complex regulatory mechanism of various organs. |
| Uses | Endothelin-1 (human, porcine) has been used for coating wells in polystyrene ELISA plates. Potent agonist for ETA and ETB endothelia receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF. |
| Application | Endothelin-1 (human, porcine) has been used: to study its effects on the production of erythropoietin under normoxia and carbon monoxide-induced hypoxia in rat models. as a protein kinase C (PKC) agonist to study its effects on the phosphorylation of myofilament proteins in rat myocytes. to induce a hypertrophic-like state to study its effects on contraction pressure in normal and mutated human induced pluripotent stem cells (hiPSC)-derived cardiomyocytes. in vitro hydrolysis products of macroendothelin-1, a precursor of endothelin-1, and their pharmacodynamic properties in rabbits. as a receptor for endothelin-1 and its role in G protein-mediated signal transduction Research. |
| Biological Functions | Endothelins are a family of vasoactive peptides secretedby endothelial cells. The three major endothelinpeptides are all composed of 21 amino acids. Endothelinsare the most potent vasoconstrictors known.Contraction of vascular smooth muscle in response toendothelin is associated with an increase in intracellularcalcium. Increases in endothelin levels have been reportedin patients with vasospastic, hypoxic, and ischemicdiseases.The two identified isoforms of endothelinreceptors have differing affinity for the three endothelinpeptides. Selective and nonselective endothelin receptorantagonists are in development for potential usein the treatment of hypertension and other disorders associatedwith increased vascular resistance. |
| Biological Activity | Endothelin 1 (human, porcine) is an endogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide isolated from porcine endothelial cells. ET-1 is widely present at binding sites in blood vessels, heart, kidneys, adrenal glands, lungs, and brain, and its distribution is similar to endothelial cells. |
| Biochem/physiol Actions | Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF. |
| storage | -20°C (desiccate) |
Endothelin-1 (human, porcine) Preparation Products And Raw materials
