Introduction：Basic information about GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN CAS 107444-51-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN Basic information
| Product Name: | GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN |
| Synonyms: | GLP-1(7-36), >98%;GLP-1(7-36),Human GLP-1-(7-36)-amide,Insulinotropin,MKC253,Glucagon-like Peptide 1 (7-36) amide, >98%;GLP-17-3;Human GLP-1-(7-36)-amide;HUMAN GLP-1-(7-36)-AMIDE; INSULINOTROPIN; MKC253; GLUCAGON-LIKE PEPTIDE 1 (7-36) AMIDE; GLP-1 (7-36) AMIDE;MKC253;GLP-1(7-36)/Glucagon-like peptide 1 (7-36) aMide (huMan, rat);glucagon-likepeptidei(7-36 |
| CAS: | 107444-51-9 |
| MF: | C149H226N40O45 |
| MW: | 3297.68 |
| EINECS: | |
| Product Categories: | Peptide;Glucagon receptor and related |
| Mol File: | 107444-51-9.mol |
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GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN Chemical Properties
| density | 1.47 |
| RTECS | LZ3980060 |
| storage temp. | −20°C |
| solubility | Soluble in DMSO |
| form | powder |
| color | White to off-white |
| Water Solubility | Soluble in water (1 mg/ml). |
| Sequence | His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2 |
| InChIKey | DTHNMHAUYICORS-KTKZVXAJSA-N |
Safety Information
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN Usage And Synthesis
| Uses | Diabetes?II?-?not?yet?an?approved?application |
| Uses | Glucagon-Like Peptide-1 is used as a Effector in the hormonal control of insulin secretion. The peptide fragment is secreted from the lower small intestine. Its action is mediated by receptors expressed by the endocrine pancreatic B-cells. |
| Uses | Glucagon-Like Peptide (GLP) I Amide Fragment 7-36 human has been used as a GLP-1 receptor agonist:
- in lysate transfer cyclic adenosine monophosphate (cAMP) assay to test its effect on adenylyl cyclase activity
- to pre-treat the human umbilical vein endothelial cells (HUVECs) to monitor its effect on hyperpermeability in endothelial cell (EC) monolayers and changes with the actin cytoskeleton
- to test its inhibitory effect on vascular endothelial growth factor-A (VEGFA) based vasodilation in rat mesenteric arteries
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| General Description | Glucagon-like peptide 1 (GLP-1) peptide is obtained from proglucagon and is metabolically inactive. However, it is processed to two smaller amide forms, namely GLP-1 (7-37) amide and GLP-1 (7-36) amide. It is a natural gastrointestinal peptide. |
| Biochem/physiol Actions | GLP-1 (glucagon-like peptide 1) (7-36) amide is a potent insulinotropic peptide, which initiates the glucose-induced insulin release after meals or oral glucose intake. It has an anti-diabetogenic effect and thus, might have use in the treatment of non-insulin dependent diabetes mellitus. |
| in vivo | Glucagon-Like Peptide (GLP) I (7-36), amide is a physiological incretin hormone that is released after nutrient intake from the lower gut and stimulates insulin secretion at elevated plasma glucose concentrations. Exogenous GLP-1 (7-36 amide) is an effective means of normalizing fasting plasma glucose concentrations in poorly-controlled Type 2 diabetic subjects[3]. Exogenously administered GLP-1-(7–36)amide is extremely labile in vivo, with more than 80% being cleaved into GLP-1-(9–36)amide after sc or iv administration[4]. |
| storage | Store at -20°C |
GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN Preparation Products And Raw materials
