Introduction：Basic information about Liensinine CAS 2586-96-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Liensinine Basic information
| Product Name: | Liensinine |
| Synonyms: | 4-[[(1r)-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-2-[[(1r)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1h-isoquinolin-7-yl]oxy]phenol;LIENSININE;Hiensinine;Liensinine4-[[(1R)-6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinyl]oxy]-;Phenol,4-[[(1R)-1,2,3,4-tetrahydro-6, 7-dimethoxy-;4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;Liensinine perchlorafe |
| CAS: | 2586-96-1 |
| MF: | C37H42N2O6 |
| MW: | 610.74 |
| EINECS: | 683-151-0 |
| Product Categories: | Alkaloids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: | 2586-96-1.mol |
|
Liensinine Chemical Properties
| Melting point | 95-99 °C |
| Boiling point | 722.0±60.0 °C(Predicted) |
| density | 1.218±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Acetone (Slightly), Chloroform (Slightly) |
| form | Solid |
| pka | 9.28±0.45(Predicted) |
| color | White to Off-White |
| InChIKey | XCUCMLUTCAKSOZ-FIRIVFDPSA-N |
| SMILES | C1(O)=CC=C(C[C@@H]2C3=C(C=C(OC)C(OC)=C3)CCN2C)C=C1OC1=CC2=C(C=C1OC)CCN(C)[C@@H]2CC1=CC=C(O)C=C1 |
Safety Information
Liensinine Usage And Synthesis
| Description | The isomer of isoliensinine (q.v.), this alkaloid is present in the embryo of the seeds of Nelumbo nucifera Gaertn. |
| Chemical Properties | Soluble in chloroform, methanol and ethanol, insoluble in ether and water. Derived from the germ of mature seeds of lotus (Nelumbo nucifera Gaevth.), Water lily family. |
| Uses | Liensinine is a bisbenzylisoquinoline alkaloid with inhibitory properties towards the activation of microglial cells. In testing with rats, iensinine decreased epileptic discharges were observed on electrocorticograms. |
| Definition | ChEBI: Liensinine is a member of isoquinolines. |
| in vivo | Liensinine (oral gavage, 100 or 200 mg/kg, daily, 10 weeks) can effectively treat periodontitis, similar to metronidazole-type drugs, and has a certain dose-dependent[2].
| Animal Model: | KM mice[2] | | Dosage: | 100 mg/kg, 200 mg/kg | | Administration: | oral gavage, daily, 10 weeks | | Result: | Reduced the gingival index and increased the SOD levels, the CAT, GSH-Px levels and decreased the NO, MDA, and ET levels compared to the control group.| Animal Model: | Institute of Cancer Research (ICR) mice (male, 20-22 g)[3] | | Dosage: | | | Administration: | 5 mg/kg by oral administration; 1 mg/kg by intravenous administration | | Result: | The pharmacokinetic parameters of Liensinine in mice
| Parameters | po (5 mg/kg) | iv (1 mg/kg) | |
| AUC(0-t) (ng/mL*h) | 18.8 ± 2.7 | 211.2 ± 54.9 | |
| AUC(0-∞) (ng/mL*h) | 19.1 ± 2.8 | 227.9 ± 60.1 | |
| MRT(0-t)( h) | 3.2 ± 0.4 | 2.6 ± 0.5 | |
| MRT(0-∞) (h) | 3.4 ± 0.5 | 3.5 ± 0.9 | |
| t1/2z (h) | 1.9 ± 0.2 | 3.8 ± 0.8 | |
| CLz/F (L/h/kg) | 266.0 ± 41.3 | 4.7 ± 1.2 | |
| Vz/F (L/kg) | 708.5 ± 79.9 | 25.9 ± 11.0 | |
| Cmax (ng/mL) | 5.3 ± 0.2 | 169.5 ± 53.5 |
|
| | References | Tse-yuan et al., Sci. Sinica., 11, 215 (1962)
Pei-chuanetal., ibid, 11,321 (1962) |
Liensinine Preparation Products And Raw materials |
