Introduction：Basic information about OREXIN B (HUMAN) CAS 205640-91-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
OREXIN B (HUMAN) Basic information
| Product Name: | OREXIN B (HUMAN) |
| Synonyms: | REF DUPL: Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2;Orexin B (huMan)Hypocretin-2 (huMan);OREXIN B HUMAN ≥98%;Orexin B (human), ≥98% (HPLC);PubChem ID: 90479794;ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2;HYPOCRETIN-2;HYPOCRETIN-2, HUMAN |
| CAS: | 205640-91-1 |
| MF: | C123H212N44O35S |
| MW: | 2899.34 |
| EINECS: | |
| Product Categories: | proteins;Peptide;Orexin receptor |
| Mol File: | 205640-91-1.mol |
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OREXIN B (HUMAN) Chemical Properties
| density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| form | lyophilized |
| Water Solubility | Soluble to 1 mg/ml in Water |
| Sequence | H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 |
Safety Information
| WGK Germany | 3 |
| HS Code | 2937190000 |
| Storage Class | 11 - Combustible Solids |
OREXIN B (HUMAN) Usage And Synthesis
| Description | Orexin B is a hypothalamic neuropeptide that regulates feeding behavior, wakefulness, and behavior under situations of high motivational relevance. It is an agonist of orexin (OX) receptors with IC50 values of 420 and 36 nM for human recombinant OX1 and OX2 receptors, respectively, expressed in CHO cells. It induces transient increases in intracellular calcium in CHO cells stably expressing OX1 and OX2 (EC50s = 2,500 and 60 nM, respectively) and in primary rat ventral tegmental area (VTA) dopaminergic neurons. Orexin B stimulates arachidonic acid release from CHO cells expressing human recombinant OX1 (EC50 = 4.17 nM). It also stimulates food intake in freely feeding mice and goldfish when administered at intracerebroventricular doses of 30 nmol and 10 ng/g, respectively. |
| Uses | Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. |
| Biochem/physiol Actions | Orexins/Hypocretins, Orexin A/ hypocretin-1 and Orexin B/ hypocretin-2, are excitatory neuropeptides that mediate there effects via two receptors, OX-1 and OX-2. Orexins are involved in food intake, obesity regulation, energy homeostasis and differentiation. |
| in vivo | Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively[2]. |
| storage | -20°C (desiccate) |
| References | [1] Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. DOI:10.1093/bja/83.5.695
[2] Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. DOI:10.1016/s0092-8674(00)80949-6 |
OREXIN B (HUMAN) Preparation Products And Raw materials
