Pheniramine CAS 86-21-5

Introduction：Basic information about Pheniramine CAS 86-21-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Pheniramine Basic information

• Product Name: Pheniramine
• Synonyms: n,n-dimethyl-3-phenyl-3-(2-pyridyl)propylamine;PHENIRAMINE;2-(alpha-(2-(dimethylamino)ethyl)benzyl)-pyridin;2-[(S)-α-[2-(Dimethylamino)ethyl]benzyl]pyridine;2-[α-(2-Dimethylaminoethyl)benzyl]pyridine;Pheniramine solution;N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine;Dexchlorpheniramine EP Impurity A
• CAS: 86-21-5
• MF: C16H20N2
• MW: 240.34
• EINECS: 201-656-2
• Mol File: 86-21-5.mol

Pheniramine Chemical Properties

• Melting point: <25 °C
• Boiling point: bp13 181°; bp2 142°; bp0.5 135°
• density: 1.0081
• refractive index: nD25 1.5519 to 1.5521
• Fp: 9℃
• storage temp.: -20°C
• solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• pka: pKa 4.03± 0.08;9.32± 0.06(H2O,t undefined,I=0.30(NaCl)) (Uncertain)
• form: Oil
• color: Colourless
• Major Application: clinical testing
• InChI: 1S/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3
• InChIKey: IJHNSHDBIRRJRN-UHFFFAOYSA-N
• SMILES: CN(C)CCC(c1ccccc1)c2ccccn2
• CAS DataBase Reference: 86-21-5(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2[alpha-(2-dimethyl aminoethyl)benzyl](86-21-5)

Safety Information

• Hazard Codes: F,T
• Risk Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 1
• Storage Class: 3 - Flammable liquids
• Hazard Classifications: Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1

Pheniramine Usage And Synthesis

Originator

Trimeton Maleate, Schering ,US,1948

Uses

Pheniramine is an antigripal drug. Also, it is derived from 2-Benzylpyridine (B288740), which is a benzylpyridine with antifungal properties. 2-Benzylpyridine is also used as a chromogenic reagent for micro determination of Molybednum.

Definition

ChEBI: N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine is a tertiary amino compound and a member of pyridines.

Manufacturing Process

According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,Ndimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid.

Therapeutic Function

Antihistaminic

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 7125, 1994 DOI: 10.1021/jo00102a044

Safety Profile

Poison by intravenousroute. Human systemic effects by ingestion:central nervous system effects. When heatedto decomposition it emits toxic fumes ofNOx.

Enzyme inhibitor

This antihistamine (FWfree-base = 240.35 g/mol; CAS 86-21-5; insoluble in water; maleate and p-aminosalicylate salts are water-soluble), also known as N,N-dimethyl-g-phenyl-2-pyridinepropanamide, is more frequently abused than other antihistamines relative to its market share. One of the histamine H1 antagonists with little sedative action, pheniramine is often used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. Target(s): H1 histamine receptor; and histamine Nmethyltransferase, mildly inhibited.

Pheniramine Preparation Products And Raw materials

• Raw materials: POTASSIUM AMIDE-->2-Benzylpyridine-->Maleic acid