CAS 136553-74-7|BE-18257B

Introduction：Basic information about CAS 136553-74-7|BE-18257B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Articles12

Common Name	BE-18257B
CAS Number	136553-74-7	Molecular Weight	612.71700
Density	1.23g/cm3	Boiling Point	1012.2ºC at 760 mmHg
Molecular Formula	C₃₁H₄₄N₆O₇	Melting Point	/
MSDS	USA	Flash Point	566ºC

Names

Name	Cyclo(-D-Glu-Ala-D-allo-Ile-Leu-D-Trp)

Chemical & Physical Properties

Density	1.23g/cm3
Boiling Point	1012.2ºC at 760 mmHg
Molecular Formula	C₃₁H₄₄N₆O₇
Molecular Weight	612.71700
Flash Point	566ºC
Exact Mass	612.32700
PSA	198.59000
LogP	2.76890
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.574

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GT9160000

CHEMICAL NAME :: Cyclo(L-alanyl-D-alloisoleucyl-L-leucyl-D-tryptophyl- D-alpha-glutamyl)

CAS REGISTRY NUMBER :: 136553-74-7

LAST UPDATED :: 199303

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C31-H44-N6-O7

MOLECULAR WEIGHT :: 612.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 44,1342,1991

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	GT9160000

Articles12

An endothelin receptor (ETA) antagonist isolated from Streptomyces misakiensis.

Biochem. Biophys. Res. Commun. 178 , 132, (1991)

A competitive endothelin (ET) antagonist, BE-18257B, was isolated from the fermentation products of Streptomyces misakiensis. It is a novel cyclic pentapeptide, cyclo(-D-Glu-L-Ala-allo-D-Ile-L-Leu-D-T...

[Agonists and antagonists to endothelin receptors].

Tanpakushitsu Kakusan Koso. 38(11) , 1827-40, (1993)

Effects of endothelin-1 and endothelin-A receptor antagonist on recovery after hypothermic cardioplegic ischemia in neonatal lamb hearts.

Circulation 92(9 Suppl) , II400-4, (1995)

Prior studies suggest an important role for coronary endothelium in ischemia/reperfusion (I/R) injury. Decreased endothelial release of the vasodilator nitric oxide occurs after I/R, but the role of t...

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