4,4'-DIHYDROXY-2-METHOXYCHALCONE CAS 34221-41-5

Introduction：Basic information about 4,4'-DIHYDROXY-2-METHOXYCHALCONE CAS 34221-41-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

4,4'-DIHYDROXY-2-METHOXYCHALCONE Basic information

• Product Name: 4,4'-DIHYDROXY-2-METHOXYCHALCONE
• Synonyms: (E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one;ECHINATIN;(E)-3-(4-Hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one;(E)-4,4'-Dihydroxy-2-methoxychalcone;4,4'-Dihydroxy-2-methoxy-trans-chalcone;ECHINATIN(RG)(CALL);4'-Dihydroxy-2-Methoxychalcone;Retrochalcone
• CAS: 34221-41-5
• MF: C16H14O4
• MW: 270.28
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;sy;Chalcones
• Mol File: 34221-41-5.mol

4,4'-DIHYDROXY-2-METHOXYCHALCONE Chemical Properties

• Melting point: 210°C (dec.)
• Boiling point: 509.8±50.0 °C(Predicted)
• density: 1.282±0.06 g/cm3 (20 ºC 760 Torr)
• storage temp.: 2-8°C
• solubility: DMSO : 250 mg/mL (924.97 mM; Need ultrasonic)
• form: powder
• pka: 7.82±0.15(Predicted)
• color: Orange
• Major Application: food and beverages
• InChI: InChI=1S/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+
• InChIKey: QJKMIJNRNRLQSS-WEVVVXLNSA-N
• SMILES: C(C1=CC=C(O)C=C1)(=O)/C=C/C1=CC=C(O)C=C1OC

Safety Information

• WGK Germany: WGK 3
• Storage Class: 11 - Combustible Solids

4,4'-DIHYDROXY-2-METHOXYCHALCONE Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from licorice root.

Uses

Echinatin is used as an anticancer agent inhibiting DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.

in vivo

Echinatin (20 and 40 mg/kg, i.p.) inhibits LPS-induced septic shock in mice by inhibiting NLRP3 inflammasome activation^[2].
Echinatin (20-80 mg/kg, i.p.) shows cardioprotective effect, and relieves I/R-Induced Myocardial Injury in rats^[3].
Echinatin (20 and 50?mg/kg, p.o.) inhibits tumor growth and inhibits the AKT/mTOR pathway of KYSE270-derived tumor mice xenografts^[4].

• Animal Model: LPS-induced septic shock in mice^[1]
• Dosage: 20 and 40 mg/kg
• Administration: i.p.
• Result: Inhibited LPS-induced IL-1β and TNF-α production. Reduced the proportion and the number of neutrophils in peritoneal lavage cells from mice.