CHRYSOERIOL CAS 491-71-4

Introduction：Basic information about CHRYSOERIOL CAS 491-71-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

CHRYSOERIOL Basic information

• Product Name: CHRYSOERIOL
• Synonyms: CHRYSOERIOL;3'-METHOXY-5,7,4'-TRIHYDROXYFLAVONE;4',5,7-TRIHYDROXY-3'-METHOXYFLAVON;4',5,7-TRIHYDROXY-3'-METHOXYFLAVONE;3’-methoxyapigenin;3’-o-methyluteolin;5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4h-1-benzopyran-4-on;chryseriol
• CAS: 491-71-4
• MF: C16H12O6
• MW: 300.26
• EINECS: 207-742-6
• Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Tetra-substituted Flavones
• Mol File: 491-71-4.mol

CHRYSOERIOL Chemical Properties

• Melting point: >300°C (dec.)
• Boiling point: 574.3±50.0 °C(Predicted)
• density: 1.512±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly, Heated and Sonicated)
• form: Solid
• pka: 6.49±0.40(Predicted)
• color: Yellow to Very Dark Yellow
• Stability: Hygroscopic
• InChI: InChI=1S/C16H12O6/c1-21-14-4-8(2-3-10(14)18)13-7-12(20)16-11(19)5-9(17)6-15(16)22-13/h2-7,17-19H,1H3
• InChIKey: SCZVLDHREVKTSH-UHFFFAOYSA-N
• SMILES: C1(C2=CC=C(O)C(OC)=C2)OC2=CC(O)=CC(O)=C2C(=O)C=1
• LogP: 2.229 (est)

Safety Information

• WGK Germany: WGK 3
• Storage Class: 11 - Combustible Solids

CHRYSOERIOL Usage And Synthesis

Uses

Chrysoeriol is a methoxyflavonoid that selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells. A metabolite of Luteolin (L475000).

Definition

ChEBI: The 3'-O-methyl derivative of luteolin.

in vivo

Chrysoeriol (1 mg/ear; external application) improves ear edema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mice, and inhibits the JAK2/STAT3 and IκB/p65 NF-κB pathways to improve inflammation^[3].

target

ERK | p38 | Akt | PI3K | mTOR | p21 | AhR | P450 (e.g. CYP17) | NOS | NF-kB | AP-1 | ROS | Potassium Channel