Introduction：Basic information about CYCLO(-GLY-PRO) CAS 3705-27-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
CYCLO(-GLY-PRO) Basic information
| Product Name: | CYCLO(-GLY-PRO) |
| Synonyms: | CYCLO(-GLY-PRO);cyclo(pro-gly);Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-, (8aS)- (9CI);(8AS)-HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE;Cyclic (Pro-Gly);(S)-3,6-Dioxohexahydropyrrolo[1,2-a]pyrazine;cyclo-GP;(8aS)-octahydropyrrolo[1,2-a]piperazine-1,4-dione |
| CAS: | 3705-27-9 |
| MF: | C7H10N2O2 |
| MW: | 154.17 |
| EINECS: | |
| Product Categories: | PYRROLE;PIPERIDINE |
| Mol File: | 3705-27-9.mol |
|
CYCLO(-GLY-PRO) Chemical Properties
| Melting point | 220-223℃ |
| Boiling point | 447.9±34.0 °C(Predicted) |
| density | 1.32 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: >10mg/mL |
| form | powder |
| pka | 13.21±0.20(Predicted) |
| Appearance | White to off-white Solid |
| Sequence | Cyclo(Pro-Gly) |
| InChI | 1S/C7H10N2O2/c10-6-4-8-7(11)5-2-1-3-9(5)6/h5H,1-4H2,(H,8,11) |
| InChIKey | OWOHLURDBZHNGG-YFKPBYRVSA-N |
| SMILES | O=C1CNC(=O)C2CCCN12 |
Safety Information
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
CYCLO(-GLY-PRO) Usage And Synthesis
| Chemical Properties | White crystal |
| Uses | Cyclo(-?Gly-?Pro) and its derivatives can be used as Cyclic Dipeptide Chitinase Inhibitors. It is also used to synthesize 5-HT1A receptor agonists. |
| Biological Activity | Cyclo-Gly-Pro is a neuro-protective compound, an endogenous diketopiperazine, which enhances memory. In the animal model of PD, the compound improved functional recovery when administered after the onset of dyskinesia. It appears th at the compound recovery function may result from non-proliferative neurogenesis th at results from the inhibition of apoptosis of stem cells and/or the promotion of neuronal-orientated proliferation in the SVZ (subventricular zone). |
CYCLO(-GLY-PRO) Preparation Products And Raw materials
