Meglumine CAS 6284-40-8
Introduction：Basic information about Meglumine CAS 6284-40-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Meglumine Basic information
| Product Name: | Meglumine |
| Synonyms: | 1-deoxy-1-(methylamino)-d-glucito;1-Deoxy-1-(methylamino)hexitol;Glucitol, 1-deoxy-1-(methylamino)-, D-;Meglumin;Methylglucamin;Methylglucamine;D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)-;D(-)-N-METHYLGLUCAMINE |
| CAS: | 6284-40-8 |
| MF: | C7H17NO5 |
| MW: | 195.21 |
| EINECS: | 228-506-9 |
| Product Categories: | Anilines, Aromatic Amines and Nitro Compounds;Aminosugars;Biochemistry;Sugars;PREDEF;Diagnostic agents;API;6284-40-8 |
| Mol File: | 6284-40-8.mol |
Meglumine Chemical Properties
| Melting point | 129-131.5 °C (lit.) |
| alpha | -16.5 º (c=10, H2O, on dry sub) |
| Boiling point | 331.88°C (rough estimate) |
| density | 1.2669 (rough estimate) |
| bulk density | 300kg/m3 |
| refractive index | -16.5 ° (C=2, H2O) |
| RTECS | LZ4295770 |
| storage temp. | 2-8°C |
| solubility | H2O: 0.1 g/mL, clear, colorless |
| form | Crystalline Powder |
| pka | pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) |
| color | White to almost white |
| PH | 11 (10g/l, H2O, 20℃) |
| biological source | synthetic (organic) |
| Optical Rotation | [α]20/D 16.5±0.5°, c = 2% in H2O |
| Water Solubility | 100 g/100 mL (25 ºC) |
| Sensitive | Air Sensitive & Hygroscopic |
| Merck | 14,6078 |
| BRN | 385906 |
| Major Application | pharmaceutical (small molecule) |
| Cosmetics Ingredients Functions | HAIR CONDITIONING |
| InChI | 1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1 |
| InChIKey | MBBZMMPHUWSWHV-VZFHVOOUSA-N |
| SMILES | CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO |
| LogP | -3.370 (est) |
| NIST Chemistry Reference | N-methylglucamine(6284-40-8) |
| EPA Substance Registry System | Meglumine (6284-40-8) |
Safety Information
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| F | 3-10-23 |
| Autoignition Temperature | ~662 °F |
| TSCA | TSCA listed |
| HS Code | 29221980 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
| Chemical Properties | white to almost white crystalline powder |
| Chemical Properties | Meglumine occurs as a white to slightly yellow-colored crystallinepowder; it is odorless or with a slight odor. |
| Uses | antiinflammatory |
| Uses | excipient in cosmetics and X-ray contrast media |
| Uses | N-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes. |
| Production Methods | Meglumine is prepared by the imination of glucose and monomethylamine,in an alcoholic solution, followed by catalytichydrogenation. |
| Definition | ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whie its antimonate is used as an antiprotozoal in the treatment of leishmaniasis. |
| Brand name | Renovue(Bracco). |
| General Description | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations. |
| Pharmaceutical Applications | Meglumine is an organic base used as a pH-adjusting agent andsolubilizing agent, primarily in the preparation of soluble salts ofiodinated organic acids used as X-ray contrast media. |
| Safety | Meglumine is widely used in parenteral pharmaceutical formulationsand is generally regarded as a nontoxic material at the levelsusually employed as an excipient. LD50 (mouse, IP): 1.68 g/kg |
| storage | Meglumine does not polymerize or dehydrate unless heated above150°C for prolonged periods. The bulk material should be stored in a well-closed container in acool, dry place. Meglumine should not be stored in aluminumcontainers since it reacts to evolve hydrogen gas; it discolors ifstored in containers made from copper or copper alloys. Stainlesssteel containers are recommended. |
| Purification Methods | Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.] |
| Incompatibilities | Incompatible with aluminum, copper, mineral acids, and oxidizingmaterials. Differential scanning calorimetry studies suggest meglumineis incompatible with glipizide. |
| Regulatory Status | Included in the FDA Inactive Ingredients Database (injections; oraltablets). Included in parenteral medicines licensed in the UK. |
| References | [1] Patent: US2014/255330, 2014, A1. Location in patent: Paragraph 0207 [2] Patent: US1994467, 1932, [3] Helvetica Chimica Acta, 1937, vol. 20, p. 83,85 [4] Chemische Berichte, 1966, vol. 99, p. 812 - 822 [5] RSC Advances, 2014, vol. 4, # 10, p. 5152 - 5155 |
Meglumine Preparation Products And Raw materials
| Raw materials | ACETALDEHYDE AMMONIA-->1-Glucose-methylamine schiffbase-->D(+)-Glucose-->Flunixin Meglumine Impurity 9-->Methylamine-->Water-->Hydrogen |
| Preparation Products | MGD SODIUM SALT MONOHYDRATE-->Delafloxacin meglumine |
