Introduction：Basic information about Polyinosinic acid-polycytidylic acid CAS 24939-03-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Polyinosinic acid-polycytidylic acid Basic information
| Product Name: | Polyinosinic acid-polycytidylic acid |
| Synonyms: | POLY(I) POLY(C);POLYINOSINIC ACID POLYCYTIDYLIC ACID;POLYINOSINIC POLYCYTIDYLIC ACID;polyinosinic:polycytidylic acid copolymer;POLYCYTIDYLIC-INOSINIC ACID;Polyinosinic-polytidylin Acid.;POLYINOSINIC ACID . POLYCYTIDYLIC ACID, LYOPHILIZED;POLYCYTIDYLIC-INOSINIC ACID POTASSIUM |
| CAS: | 24939-03-5 |
| MF: | C19H27N7O16P2 |
| MW: | 671.41 |
| EINECS: | 1308068-626-2 |
| Product Categories: | Material |
| Mol File: | 24939-03-5.mol |
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Polyinosinic acid-polycytidylic acid Chemical Properties
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble to 3 mg/ml in water |
| Stability: | Hygroscopic |
| InChIKey | ACEVNMQDUCOKHT-WOQDZEJINA-N |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,22,23,24,32,r| |
Safety Information
| WGK Germany | 3 |
| RTECS | TR0175000 |
Polyinosinic acid-polycytidylic acid Usage And Synthesis
| Uses | Poly(I:C) is a toll-like receptor 3 dsRNA inflammatory stimulant. |
| Definition | ChEBI: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid. |
| Biological Activity | poly (i:c), a synthetic double-stranded rna (dsrna) analog, is an immunostimulant that acts as the most potent interferon (ifn) inducer. toll-like receptor- 3 (tlr3) agonist[1].mixtures that included the tlr7/8 agonists r848 or cl075, combined with the poly (i:c), yield 3-d mature dendritic cells [2].commonly used to stimulate immune system activation in vivo. also promotes maturation of hpsc-derived cardiomyocytes[3].[1]. li y g, siripanyaphinyo u, tumkosit u, et al. poly (i:c), an agonist of toll-like receptor-3, inhibits replication of the chikungunya virus in beas-2b cells. virology journal, 2012, 9(1): 114.[2]. spranger s, javorovic m, burdek m, et al. generation of th1-polarizing dendritic cells using the tlr7/8 agonist cl075. the journal of immunology, 2010, 185(1): 738-747.[3]. biermann m1, cai w2, lang d, et al. epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation. stem cells, 2019, 37(7): 910-923. |
| in vivo | Polyinosinic-polycytidylic acid (2.5-10 mg/mL, Stereotaxic injection, single dose) induces a sustained inflammatory reaction in the substantia nigra (SN) and in the dorsolateral striatum. [2].
Polyinosinic-polycytidylic acid (10 μg/mouse, Intraperitoneal injection, single dose) decreases lung tumor growth in mice[3].
Polyinosinic-polycytidylic acid (1.25 mg/kg, Intraperitoneal injection, single dose) exerts therapeutic effects against cerebral I/R injury through the downregulation of TLR4/MyD88 signaling via TLR3 in MCAO model mice[5]. | Animal Model: | lung tumor-bearing mice[3] | | Dosage: | 10 μg/mouse | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Induced a significant decrease in the growth of pulmonary metastases in tumor-bearing mice.Reduced the amount of lung foci to ≈ 40%.Significantly increased BAL fluid cell numbers. Increased the level of INF-γ and IL-17A, decreased the levels of IL-13.Increased TLR3 expression.| Animal Model: | Middle cerebral artery occlusion (MCAO) model mice[5] | | Dosage: | 1.25 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Reduced focal cerebral I/R injury.Increased the expression of Bcl2, Hsp27, and Hsp70, decreased Bax expression, and reduced cellular degeneration and apoptosis.Protected against cerebral ischemia and conferred protection against cerebral I/R injury through the downregulation of TLR4 signaling via TLR3. |
| | IC 50 | Bcl-2; Bax; IL-17A; IL-13; HSP70 |
Polyinosinic acid-polycytidylic acid Preparation Products And Raw materials| Raw materials | Sodium nitrite-->Epichlorohydrin-->Morpholine-->Ammonium sulfate-->SULFATE STANDARD-->Microcrystalline cellulose-->Ribonucleic acid-->Agar-->Tributylamine-->Inosinic Acid-->Creatine-->5'—NUCLEOTIDE-->Cytidine 5’-monophosphate-->POLYNUCLEOTIDE PHOSPHORYLASE FROM BACIL-->Yttrium oxide sulfate, terbium-doped-->TAQ DNA POLYMERASE 5U/UL |
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