Introduction：Basic information about Polyinosinic-polycytidylic acid sodium salt CAS 42424-50-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Polyinosinic-polycytidylic acid sodium salt Basic information
| Product Name: | Polyinosinic-polycytidylic acid sodium salt |
| Synonyms: | POLYINOSINIC ACID + POLYCYTIDYLIC ACID, SODIUM SALT;Polymyocyte sodium salt;POLYINOSINIC ACID POLYCYTIDYLIC ACID, SODIUM SALT;POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT;POLY I POLY C, NA;POLY[I] POLY[C] SODIUM SALT;Oligochitosan-kanamycin-polyI-polyC sodium salt compound solution;Polyinosinic acid - polycytidylic acid sodium salt, double-stranded |
| CAS: | 42424-50-0 |
| MF: | C19H27N7O16P2 |
| MW: | 671.41 |
| EINECS: | 1308068-626-2 |
| Product Categories: | Biochemicals and Reagents;Biomaterials;Cell Culture;Materials Science;Nucleosides;Nucleotides;Oligonucleotide Polymers and Copolymers;Oligonucleotides;Other adjuvants;Synthetic Oligonucleotides and Related Reagents;Vaccine Adjuvants;Vaccine Production;Nucleoside Mono |
| Mol File: | 42424-50-0.mol |
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Polyinosinic-polycytidylic acid sodium salt Chemical Properties
| storage temp. | −20°C |
| solubility | H2O: soluble10mg/mL |
| form | lyophilized powder |
| color | White to off-white |
| biological source | synthetic (organic) |
| Water Solubility | Water : 10 mg/mL (Need ultrasonic and warming) |
| InChIKey | ACEVNMQDUCOKHT-WOQDZEJINA-N |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=NC2C(NC=NC1=2)=O)O |&1:1,2,3,11,22,23,24,32,r| |
Safety Information
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | TR0175000 |
| Storage Class | 11 - Combustible Solids |
Polyinosinic-polycytidylic acid sodium salt Usage And Synthesis
| Description | Polyinosinic-polycytidylic acid (Poly I:C) sodium salt (double-stranded) is a TLR3 (Toll-like receptor 3) agonist. |
| Uses | TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic-polycytidylic acid sodium salt is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly I:C is a TRIF-dependent toll-like receptor-3 (TLR3) ligand. |
| Biological Activity | Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis. |
| in vivo | Polyinosinic-polycytidylic acid (Poly I:C) treatment inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells. The level of human DNA is 50% lower in mice treated with Polyinosinic-polycytidylic acid[1]. |
| IC 50 | TLR3 |
| storage | Store at -20°C |
Polyinosinic-polycytidylic acid sodium salt Preparation Products And Raw materials
