CORTISOL-9,11,12,12-D4 CAS 73565-87-4
Introduction：Basic information about CORTISOL-9,11,12,12-D4 CAS 73565-87-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
CORTISOL-9,11,12,12-D4 Basic information
| Product Name: | CORTISOL-9,11,12,12-D4 |
| Synonyms: | 17-Hydroxycorticosterone-9,11,12,12-d4, Cortisol-9,11,12,12-d4, Hydrocortisone-9,11,12,12-d4, Kendall's compound F (9,11,12,12-d4), Reichstein's substance M (9,11,12,12-d4), 4-Pregnene-11β,17α,21-triol-3,20-dione-d4 (9,11,12,12-d4), 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-d4 (9,11,12,12-d4);CORTISOL-9,11,12,12-D4;HYDROCORTISONE (9,11,12,12-D4);Cortisol-D4 (9,11,12,12-D4);(11β)-11,17,21-Trihydroxy-pregn-4-ene-3,20-dione-d4;11β-Hydroxycortisone-d4;17-Hydroxycorticosterone-d4;Acticort-d4 |
| CAS: | 73565-87-4 |
| MF: | C21H26D4O5 |
| MW: | 366.49 |
| EINECS: | 694-327-1 |
| Product Categories: | Steroids & Hormones - 13C & 2H;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals;Steroids |
| Mol File: | 73565-87-4.mol |
CORTISOL-9,11,12,12-D4 Chemical Properties
| Melting point | 211-214 °C |
| Fp | 9℃ |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly, Heated), Water |
| form | Solid |
| color | White to Off-White |
| Appearance | white powder |
| Major Application | clinical testing clinical testing |
| InChIKey | JYGXADMDTFJGBT-BJJKTIQHSA-N |
| SMILES | [2H]C1([2H])[C@]([2H])(O)[C@@]2([2H])[C@@H](CCC3=CC(=O)CC[C@]23C)[C@@H]4CCC(O)(C(=O)CO)[C@@]14C |
| CAS Number Unlabeled | 50-23-7 |
Safety Information
| Hazard Codes | Xn,T,F |
| Risk Statements | 63-39/23/24/25-23/24/25-11 |
| Safety Statements | 36/37-45-16-7 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1 |
| Description | Hydrocortisone-d4 is intended for use as an internal standard for the quantification of hydrocortisone/cortisol by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson''s disease. |
| Chemical Properties | White Solid |
| Uses | Labelled Cortisol (H714615). Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism. |
| Uses | Anti-inflammatory hormone |
| General Description | Cortisol, also known as hydrocortisone, is a glucocorticoid produced by the adrenal gland. This stable labeled internal standard is suitable for quantitation of cortisol levels in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing′s syndrome, Addison′s disease, and Sheehan′s syndrome. |
| References | [1] KRIEGER D T. Rhythms of acth and corticosteroid secretion in health and disease, and their experimental modification[J]. Journal of steroid biochemistry, 1975, 6 5: Pages 785-791. DOI: 10.1016/0022-4731(75)90068-0 [2] BOADIE W. DUNLOP Andrea W. The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions[J]. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2019, 89: Pages 361-379. DOI: 10.1016/j.pnpbp.2018.10.010 [3] PAUL M. STEWART Christopher R W E. The cortisol-cortisone shuttle and hypertension[J]. Journal of Steroid Biochemistry and Molecular Biology, 1991, 40 4: Pages 501-509. DOI: 10.1016/0960-0760(91)90269-b [4] FEMINA P. VARGHESE E S B. The Hypothalamic-Pituitary-Adrenal Axis in Major Depressive Disorder: A Brief Primer for Primary Care Physicians.[J]. Primary care companion to the Journal of clinical psychiatry, 2001, 3 4: 151-155. DOI: 10.4088/pcc.v03n0401 [5] NAYRON MEDEIROS SOARES. Cortisol levels, motor, cognitive and behavioral symptoms in Parkinson’s disease: a systematic review.[J]. Journal of Neural Transmission, 2019, 126 3: 219-232. DOI: 10.1007/s00702-018-1947-4 |
CORTISOL-9,11,12,12-D4 Preparation Products And Raw materials
