Nucleoside phosphorylase CAS 9030-21-1

Introduction：Basic information about Nucleoside phosphorylase CAS 9030-21-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Nucleoside phosphorylase Basic information

• Product Name: Nucleoside phosphorylase
• Synonyms: Nucleoside Phosphorylase bacterial,PNP, Purine nucleoside phosphorylase, Purine nucleoside:orthophosphate ribosyltransferase;Purine nucleoside phosphorylase [ >=200 units/mg];Deoxyribonucleoside phosphorylase;Purine deoxynucleoside phosphorylase;Purine deoxyribonucleoside phosphorylase;Purine ribonucleoside phosphorylase;PNP/Purine-nucleoside phosphorylase;Nucleoside Phosphorylase from microorganisms
• CAS: 9030-21-1
• MF: C10H12N4O4
• MW: 252.22668
• EINECS: 232-857-3
• Mol File: 9030-21-1.mol

Nucleoside phosphorylase Chemical Properties

• storage temp.: -20°C
• form: lyophilized powder
• color: White to off-white
• Specific Activity: ≥9U/mL
• InChI: InChI=1/C10H12N4O4/c15-2-6-7(16)8(17)10(18-6)14-4-13-5-1-11-3-12-9(5)14/h1,3-4,6-8,10,15-17H,2H2/t6-,7-,8-,10-/s3
• InChIKey: MRWXACSTFXYYMV-DOGWMMLDNA-N
• SMILES: O1[C@@H](N2C3=C(N=C2)C=NC=N3)[C@H](O)[C@H](O)[C@H]1CO |&1:1,11,13,15,r|

Safety Information

• Hazard Codes: B
• Safety Statements: 22-24/25
• WGK Germany: 3
• HS Code: 35079090
• Storage Class: 12 - Non Combustible Liquids

Nucleoside phosphorylase Usage And Synthesis

Chemical Properties

Powder

Uses

Nucleoside Phosphorylase from microorganisms has been used:

• in phosphopentomutase assay for adenosine synthesis
• for the conversion of 7-methylthioguanosine to 7-methylthioguanine
• in the synthesis of cytokinins in lyophilized cotton plant samples

General Description

Nucleoside Phosphorylase are trimeric and have a molecular mass of about 100 kDa. Each monomer consists of a mixed β-sheet core flanked by eight α-helices and a purine binding in hydrophobic pocket.

Biochem/physiol Actions

Purine nucleoside phosphorylase is an enzyme involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine. Mutations in the PNP gene are responsible for purine nucleoside phosphorylase deficiency.