Amyloid β-Peptide (1-42) (human) CAS 107761-42-2

Introduction：Basic information about Amyloid β-Peptide (1-42) (human) CAS 107761-42-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Amyloid β-Peptide (1-42) (human) Basic information

• Product Name: Amyloid β-Peptide (1-42) (human)
• Synonyms: Bate-Amyloid（1-42）human; (1-42) (human);AB42, betaamyloid peptide;Amyloid βH-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH;REF DUPL: H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH;Beta-Amyloid (1-42), sodium salt;Β-AMYLOID PEPTIDE (1-42), RAT
• CAS: 107761-42-2
• MF: C203H311N55O60S1
• MW: 4514.04
• EINECS: 761-142-2
• Product Categories: Neuroscience;Signalling;proteins;Peptide;Amyloid beta Protein Fragments;Amyloid β Protein FragmentsNeuropeptides;Alzheimers and Neurodegenerative Disease Research;Neurodegenerative Disease Peptides;β Amyloid Peptides;Amyloid beta-peptide and related;TB500;107761-42-2
• Mol File: 107761-42-2.mol

Amyloid β-Peptide (1-42) (human) Chemical Properties

• Melting point: 205 °C
• density: 0.23 g/cm3
• storage temp.: -20°C
• solubility: Soluble in ammonium hydroxide, pH >9. Also soluble in DMSO.
• form: Lyophilized
• color: Lyophilized White
• Odor: Odorless
• Sequence: H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
• InChIKey: XPESWQNHKICWDY-QYFPAAMGSA-N
• CAS DataBase Reference: 107761-42-2(CAS DataBase Reference)

Safety Information

• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29332900
• Storage Class: 11 - Combustible Solids

Amyloid β-Peptide (1-42) (human) Usage And Synthesis

Chemical Properties

Lyophilized White solid, with no soy flavor, no protein denaturation, acidic non-precipitation, heating does not coagulate, easily soluble in water, good fluidity, and other good processing properties, is an excellent health food material.

Uses

Amyloid β-Peptide (1-42) (human)[107761-42-2], a major component of amyloid plaques, accumulates in neurons of Alzheimer's disease brains. Aβ(s) peptides, their peptide fragments and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding and mechanisms of protein cross-linking in the context of diseases such as Alzheimer's disease and neurodegeneration.

Application

Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Beta-Amyloid (1-42) human is used as follows:
for the production of Aβ-1-42 oligomer;
in western blot analysis;
for interference testing of immunomagnetic reduction (IMR) plasma Aβ42 assay;
to study the effect of resveratrol on Aβ-1-42-induced impairment of spatial learning, memory, and synaptic plasticity;
to investigate the effect of Aβ in epithelial cell cultures.

General Description

Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3.

Biochem/physiol Actions

Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.

storage

-20°C

References

[1] CHEN L M, CHAI K X. Matriptase cleaves the amyloid-beta peptide 1–42 at Arg-5, Lys-16, and Lys-28[J]. BMC Research Notes, 2019, 12. DOI:10.1186/s13104-018-4040-z.
[2] BROWN A M, BEVAN D R. Influence of sequence and lipid type on membrane perturbation by human and rat amyloid β-peptide (1-42).[J]. Archives of biochemistry and biophysics, 2015, 614: 1-13. DOI:10.1016/j.abb.2016.11.006.
[3] MENGTING YANG. Gel Phase Membrane Retards Amyloid β-Peptide (1–42) Fibrillation by Restricting Slaved Diffusion of Peptides on Lipid Bilayers[J]. Langmuir, 2018, 34 28: 8408-8414. DOI:10.1021/acs.langmuir.8b01315.
[4] LIANG SHEN Hong F J. Comparative study on the conformational stability of human and murine amyloid β peptide[J]. Computational and Theoretical Chemistry, 2011, 972 1: Pages 44-47. DOI:10.1016/j.comptc.2011.06.012.
[5] MOUCHARD A, BOUTONNET M C, MAZZOCCO C, et al. ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer’s disease[J]. Scientific Reports, 2019, 9. DOI:10.1038/s41598-019-40438-4.

Amyloid β-Peptide (1-42) (human) Preparation Products And Raw materials

• Raw materials: Bacillus subtilis-->SOYBEAN MEAL-->Complex enzyme-->Subtilisin-->PROTEASE